WELLBUTRIN SR vs ZYBAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	WELLBUTRIN SR	ZYBAN
Rating	70/100	70/100
Pharmacy pays	~$2.52 /30	~$2.52 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE	BUPROPION HYDROCHLORIDE
Manufacturer	Glaxosmithkline	Glaxosmithkline
Dosage forms	Tablet	Tablet, extended release
Drug class	Aminoketone	Aminoketone
Boxed warning	Boxed warning	None
Half-life	about 21 hours on average (±9 hours)	about 21 hours on average (±9 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

wellbutrin sr zyban

Rating

70/100

Pharmacy pays

~$2.52 /30

Type

Active ingredient

BUPROPION HYDROCHLORIDE

Manufacturer

Glaxosmithkline

Dosage forms

Tablet

Tablet, extended release

Drug class

Aminoketone

Boxed warning

None

Half-life

about 21 hours on average (±9 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

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Frequently asked questions

Which is better-rated, Wellbutrin SR or Zyban?

Wellbutrin SR and Zyban are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Wellbutrin SR or Zyban?

Pharmacies pay about the same to acquire either one — roughly $2.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Wellbutrin SR and Zyban?

Both Wellbutrin SR and Zyban share the active ingredient Bupropion Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.