WELLBUTRIN SR vs WELLBUTRIN XL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	WELLBUTRIN SR	WELLBUTRIN XL
Rating	70/100	New
Pharmacy pays	~$2.52 /30	~$2.52 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE	BUPROPION HYDROCHLORIDE
Manufacturer	Glaxosmithkline	Bausch
Dosage forms	Tablet	Tablet, extended release
Drug class	Aminoketone	Aminoketone
Boxed warning	Boxed warning	Boxed warning
Half-life	about 21 hours on average (±9 hours)	about 21 hours on average (±9 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

wellbutrin sr wellbutrin xl

Rating

70/100

New

Pharmacy pays

~$2.52 /30

Type

Active ingredient

BUPROPION HYDROCHLORIDE

Manufacturer

Glaxosmithkline

Bausch

Dosage forms

Tablet

Tablet, extended release

Drug class

Aminoketone

Boxed warning

Half-life

about 21 hours on average (±9 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

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Frequently asked questions

Which is cheaper, Wellbutrin SR or Wellbutrin XL?

Pharmacies pay about the same to acquire either one — roughly $2.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Wellbutrin SR and Wellbutrin XL?

Both Wellbutrin SR and Wellbutrin XL share the active ingredient Bupropion Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.