VOLTAREN-XR vs ZIPSOR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. VOLTAREN-XR and ZIPSOR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	VOLTAREN-XR	ZIPSOR
Rating	70/100	New
Pharmacy pays	$0.36 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	DICLOFENAC SODIUM	DICLOFENAC POTASSIUM
Manufacturer	Novartis	Assertio Speclty
Dosage forms	Tablet, extended release	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

voltaren-xr zipsor

Rating

70/100

New

Pharmacy pays

$0.36 /mL

Type

Active ingredient

DICLOFENAC SODIUM

DICLOFENAC POTASSIUM

Manufacturer

Novartis

Assertio Speclty

Dosage forms

Tablet, extended release

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Voltaren-XR or Zipsor?

Pharmacies pay about the same to acquire either one — roughly $0.36 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Voltaren-XR and Zipsor?

Voltaren-XR contains Diclofenac Sodium, while Zipsor contains Diclofenac Potassium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.