VIVELLE vs VIVELLE-DOT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	VIVELLE	VIVELLE-DOT
Rating	68/100	68/100
Pharmacy pays	$6.55 /g	$6.55 /g
Type	RX	RX
Active ingredient	ESTRADIOL	ESTRADIOL
Manufacturer	Sandoz	Sandoz
Dosage forms	System, Film, extended release	Patch, extended release
Drug class	Estrogen	Estrogen
Boxed warning	None	Boxed warning
Treats	Breast Neoplasms, Hypogonadism, Premature Menopause	Breast Neoplasms, Hypogonadism, Premature Menopause

vivelle vivelle-dot

Rating

68/100

Pharmacy pays

$6.55 /g

Type

Active ingredient

ESTRADIOL

Manufacturer

Sandoz

Dosage forms

System, Film, extended release

Patch, extended release

Drug class

Estrogen

Boxed warning

None

Boxed warning

Treats

Breast Neoplasms, Hypogonadism, Premature Menopause

Frequently asked questions

Which is better-rated, Vivelle or Vivelle-Dot?

Vivelle and Vivelle-Dot are tied at 3.4 out of 5 by our independent rating.

Which is cheaper, Vivelle or Vivelle-Dot?

Pharmacies pay about the same to acquire either one — roughly $6.55 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Vivelle and Vivelle-Dot?

Both Vivelle and Vivelle-Dot share the active ingredient Estradiol.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.