VAGIFEM vs VIVELLE-DOT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	VAGIFEM	VIVELLE-DOT
Rating	70/100	68/100
Pharmacy pays	$6.55 /g	$6.55 /g
Type	RX	RX
Active ingredient	ESTRADIOL	ESTRADIOL
Manufacturer	Novo Nordisk Inc	Sandoz
Dosage forms	Insert	Patch, extended release
Drug class	Estrogen	Estrogen
Boxed warning	Boxed warning	Boxed warning
Treats	Breast Neoplasms, Hypogonadism, Premature Menopause	Breast Neoplasms, Hypogonadism, Premature Menopause

vagifem vivelle-dot

Rating

70/100

68/100

Pharmacy pays

$6.55 /g

Type

Active ingredient

ESTRADIOL

Manufacturer

Novo Nordisk Inc

Sandoz

Dosage forms

Insert

Patch, extended release

Drug class

Estrogen

Boxed warning

Treats

Breast Neoplasms, Hypogonadism, Premature Menopause

Frequently asked questions

Which is better-rated, Vagifem or Vivelle-Dot?

By our independent rating, Vagifem scores higher — 3.5 vs 3.4 out of 5 for Vivelle-Dot. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Vagifem or Vivelle-Dot?

Pharmacies pay about the same to acquire either one — roughly $6.55 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Vagifem and Vivelle-Dot?

Both Vagifem and Vivelle-Dot share the active ingredient Estradiol.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.