UNISOM vs VISTARIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. UNISOM and VISTARIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	UNISOM	VISTARIL
Rating	64/100	64/100
Pharmacy pays	—	$0.04 /mL
Type	RX	RX
Active ingredient	DOXYLAMINE SUCCINATE	HYDROXYZINE HYDROCHLORIDE
Manufacturer	Pfizer	Pfizer
Dosage forms	Capsule, Tablet	Capsule, Injectable
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Half-life	—	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)
Treats	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis	Anxiety Disorders, Nausea, Pruritus

unisom vistaril

Rating

64/100

Pharmacy pays

—

$0.04 /mL

Type

Active ingredient

DOXYLAMINE SUCCINATE

HYDROXYZINE HYDROCHLORIDE

Manufacturer

Pfizer

Dosage forms

Capsule, Tablet

Capsule, Injectable

Drug class

Antihistamine

Boxed warning

None

Half-life

—

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

Treats

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

Anxiety Disorders, Nausea, Pruritus

Get unisomhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

Which is better-rated, Unisom or Vistaril?

Unisom and Vistaril are tied at 3.2 out of 5 by our independent rating.

What is the difference between Unisom and Vistaril?

Unisom contains Doxylamine Succinate, while Vistaril contains Hydroxyzine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.