ULTRAM vs XTAMPZA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. ULTRAM and XTAMPZA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ULTRAM	XTAMPZA ER
Rating	70/100	New
Pharmacy pays	~$0.72 /30	$0.08 /mL
Type	RX	RX
Active ingredient	TRAMADOL HYDROCHLORIDE	OXYCODONE
Manufacturer	Janssen Pharms	Collegium Pharm Inc
Dosage forms	Tablet	Capsule, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)	about 3.5 to 4 hours
Treats	Pain	Postoperative Pain

ultram xtampza er

Rating

70/100

New

Pharmacy pays

~$0.72 /30

$0.08 /mL

Type

Active ingredient

TRAMADOL HYDROCHLORIDE

OXYCODONE

Manufacturer

Janssen Pharms

Collegium Pharm Inc

Dosage forms

Tablet

Capsule, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

about 3.5 to 4 hours

Treats

Pain

Postoperative Pain

Frequently asked questions

What is the difference between Ultram and Xtampza ER?

Ultram contains Tramadol Hydrochloride, while Xtampza ER contains Oxycodone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.