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ULTRAM vs VANTRELA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. ULTRAM and VANTRELA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

ultramvantrela er

Rating

70/100
New

Pharmacy pays

~$0.72 /30
~$239.83 /30

Type

RX
RX

Active ingredient

TRAMADOL HYDROCHLORIDE
HYDROCODONE BITARTRATE

Manufacturer

Janssen Pharms
Teva Branded Pharm

Dosage forms

Tablet
Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
about 3.8 hours (3.8 ± 0.3 hours)

Treats

Pain
Cough, Obstructive Lung Diseases, Postoperative Pain

Frequently asked questions

Which is cheaper, Ultram or Vantrela ER?

Ultram costs pharmacies less to acquire — about $0.72 vs $239.83 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Ultram and Vantrela ER?

Ultram contains Tramadol Hydrochloride, while Vantrela ER contains Hydrocodone Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.