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ACETAMINOPHEN vs TYLENOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Rating

68/100
70/100

Pharmacy pays

$0.03 /mL
$0.03 /mL

Type

RX
OTC

Active ingredient

ACETAMINOPHEN
ACETAMINOPHEN

Dosage forms

Injectable, Suspension, Tablet, Tablet, extended release
Tablet, extended release

Drug class

Boxed warning

Treats

Fever, Pain
Fever, Pain

Get tylenolhigher-rated option

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Acetaminophen or Tylenol?

By our independent rating, Tylenol scores higher — 3.5 vs 3.4 out of 5 for Acetaminophen. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Acetaminophen or Tylenol?

Pharmacies pay about the same to acquire either one — roughly $0.03 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Acetaminophen and Tylenol?

Both Acetaminophen and Tylenol share the active ingredient Acetaminophen, but Acetaminophen is sold as RX and Tylenol as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.