TOLSURA vs TRIVAGIZOLE 3

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	TOLSURA	TRIVAGIZOLE 3
Rating	70/100	New
Pharmacy pays	$0.84 /mL	$0.21 /mL
Type	RX	OTC
Active ingredient	ITRACONAZOLE	CLOTRIMAZOLE
Manufacturer	Mayne Pharma	Sun Pharma Canada
Dosage forms	Capsule	Topical
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	Boxed warning	None
Half-life	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.	—
Treats	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

tolsura trivagizole 3

Rating

70/100

New

Pharmacy pays

$0.84 /mL

$0.21 /mL

Type

OTC

Active ingredient

ITRACONAZOLE

CLOTRIMAZOLE

Manufacturer

Mayne Pharma

Sun Pharma Canada

Dosage forms

Capsule

Topical

Drug class

Azole Antifungal

Boxed warning

None

Half-life

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

—

Treats

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

Which is cheaper, Tolsura or Trivagizole 3?

Trivagizole 3 costs pharmacies less to acquire — about $0.21 vs $0.84 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Tolsura and Trivagizole 3?

Tolsura contains Itraconazole, while Trivagizole 3 contains Clotrimazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.