TOFRANIL-PM vs ZONALON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. TOFRANIL-PM and ZONALON are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	TOFRANIL-PM	ZONALON
Rating	70/100	66/100
Pharmacy pays	~$100.18 /30	~$4.84 /30
Type	RX	RX
Active ingredient	IMIPRAMINE PAMOATE	DOXEPIN HYDROCHLORIDE
Manufacturer	Specgx LLC	Mylan
Dosage forms	Capsule	Topical
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	—	about 8 to 24 hours (average about 17 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

tofranil-pm zonalon

Rating

70/100

66/100

Pharmacy pays

~$100.18 /30

~$4.84 /30

Type

Active ingredient

IMIPRAMINE PAMOATE

DOXEPIN HYDROCHLORIDE

Manufacturer

Specgx LLC

Mylan

Dosage forms

Capsule

Topical

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

—

about 8 to 24 hours (average about 17 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Tofranil-Pm or Zonalon?

By our independent rating, Tofranil-Pm scores higher — 3.5 vs 3.3 out of 5 for Zonalon. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Tofranil-Pm or Zonalon?

Zonalon costs pharmacies less to acquire — about $4.84 vs $100.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Tofranil-Pm and Zonalon?

Tofranil-Pm contains Imipramine Pamoate, while Zonalon contains Doxepin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.