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TAZAROTENE vs TRETINOIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. TAZAROTENE and TRETINOIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
68/100

Pharmacy pays

$6.80 /g
$1.05 /g

Type

RX
RX

Active ingredient

TAZAROTENE
TRETINOIN

Dosage forms

Topical
Capsule, Topical

Drug class

Retinoid
Retinoid

Boxed warning

None
None

Treats

Acne Vulgaris, Psoriasis
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Tazarotene or Tretinoin?

By our independent rating, Tazarotene scores higher — 3.5 vs 3.4 out of 5 for Tretinoin. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Tazarotene or Tretinoin?

Tretinoin costs pharmacies less to acquire — about $1.05 vs $6.80 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Tazarotene and Tretinoin?

Tazarotene contains Tazarotene, while Tretinoin contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.