TALZENNA vs TOLAK

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. TALZENNA and TOLAK are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	TALZENNA	TOLAK
Rating	64/100	72/100
Pharmacy pays	—	$0.61 /mL
Type	RX	RX
Active ingredient	TALAZOPARIB TOSYLATE	FLUOROURACIL
Manufacturer	Pfizer	Hill Dermaceuticals
Dosage forms	Capsule	Topical
Drug class	Poly(Adp-Ribose) Polymerase Inhibitor	Nucleoside Metabolic Inhibitor
Boxed warning	None	None
Treats	Breast Neoplasms	Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

talzenna tolak

Rating

64/100

72/100

Pharmacy pays

—

$0.61 /mL

Type

Active ingredient

TALAZOPARIB TOSYLATE

FLUOROURACIL

Manufacturer

Pfizer

Hill Dermaceuticals

Dosage forms

Capsule

Topical

Drug class

Poly(Adp-Ribose) Polymerase Inhibitor

Nucleoside Metabolic Inhibitor

Boxed warning

None

Treats

Breast Neoplasms

Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

Frequently asked questions

Which is better-rated, Talzenna or Tolak?

By our independent rating, Tolak scores higher — 3.6 vs 3.2 out of 5 for Talzenna. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Talzenna and Tolak?

Talzenna contains Talazoparib Tosylate, while Tolak contains Fluorouracil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.