SUFENTA PRESERVATIVE FREE vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. SUFENTA PRESERVATIVE FREE and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SUFENTA PRESERVATIVE FREE	ULTRAM
Rating	72/100	70/100
Pharmacy pays	—	~$0.72 /30
Type	RX	RX
Active ingredient	SUFENTANIL CITRATE	TRAMADOL HYDROCHLORIDE
Manufacturer	Rising	Janssen Pharms
Dosage forms	Injectable	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Pain	Pain

sufenta preservative free ultram

Rating

72/100

70/100

Pharmacy pays

—

~$0.72 /30

Type

Active ingredient

SUFENTANIL CITRATE

TRAMADOL HYDROCHLORIDE

Manufacturer

Rising

Janssen Pharms

Dosage forms

Injectable

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain

Frequently asked questions

Which is better-rated, Sufenta Preservative Free or Ultram?

By our independent rating, Sufenta Preservative Free scores higher — 3.6 vs 3.5 out of 5 for Ultram. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Sufenta Preservative Free and Ultram?

Sufenta Preservative Free contains Sufentanil Citrate, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.