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SUBLIMAZE PRESERVATIVE FREE vs XTAMPZA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. SUBLIMAZE PRESERVATIVE FREE and XTAMPZA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

$9.51 /mL
$0.08 /mL

Type

RX
RX

Active ingredient

FENTANYL CITRATE
OXYCODONE

Dosage forms

Injectable
Capsule, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 3.5 to 4 hours

Treats

Pain
Postoperative Pain

Frequently asked questions

Which is cheaper, Sublimaze Preservative Free or Xtampza ER?

Xtampza ER costs pharmacies less to acquire — about $0.08 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Sublimaze Preservative Free and Xtampza ER?

Sublimaze Preservative Free contains Fentanyl Citrate, while Xtampza ER contains Oxycodone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.