SUBLIMAZE PRESERVATIVE FREE vs TAPENTADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. SUBLIMAZE PRESERVATIVE FREE and TAPENTADOL HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SUBLIMAZE PRESERVATIVE FREE	TAPENTADOL HYDROCHLORIDE
Rating	72/100	New
Pharmacy pays	$9.51 /mL	~$335.93 /30
Type	RX	RX
Active ingredient	FENTANYL CITRATE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Rising	Humanwell
Dosage forms	Injectable	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Pain	Pain

sublimaze preservative free tapentadol hydrochloride

Rating

72/100

New

Pharmacy pays

$9.51 /mL

~$335.93 /30

Type

Active ingredient

FENTANYL CITRATE

TAPENTADOL HYDROCHLORIDE

Manufacturer

Rising

Humanwell

Dosage forms

Injectable

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain

Frequently asked questions

What is the difference between Sublimaze Preservative Free and Tapentadol Hydrochloride?

Sublimaze Preservative Free contains Fentanyl Citrate, while Tapentadol Hydrochloride contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.