SINEQUAN vs ZONALON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	SINEQUAN	ZONALON
Rating	64/100	66/100
Pharmacy pays	~$4.84 /30	~$4.84 /30
Type	RX	RX
Active ingredient	DOXEPIN HYDROCHLORIDE	DOXEPIN HYDROCHLORIDE
Manufacturer	Pfizer	Mylan
Dosage forms	Capsule	Topical
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	about 8 to 24 hours (average about 17 hours)	about 8 to 24 hours (average about 17 hours)
Treats	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

sinequan zonalon

Rating

64/100

66/100

Pharmacy pays

~$4.84 /30

Type

Active ingredient

DOXEPIN HYDROCHLORIDE

Manufacturer

Pfizer

Mylan

Dosage forms

Capsule

Topical

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

about 8 to 24 hours (average about 17 hours)

Treats

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Sinequan or Zonalon?

By our independent rating, Zonalon scores higher — 3.3 vs 3.2 out of 5 for Sinequan. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Sinequan or Zonalon?

Pharmacies pay about the same to acquire either one — roughly $4.84 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Sinequan and Zonalon?

Both Sinequan and Zonalon share the active ingredient Doxepin Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.