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SILVADENE vs SODIUM SULFACETAMIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. SILVADENE and SODIUM SULFACETAMIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

$0.25 /g
$0.11 /g

Type

RX
RX

Active ingredient

SILVER SULFADIAZINE
SULFACETAMIDE SODIUM

Dosage forms

Topical
Liquid, Topical

Drug class

Sulfonamide Antibacterial
Sulfonamide Antibacterial

Boxed warning

None
None

Treats

Wound Infection
Corneal Ulcer, Ear Diseases, Seborrheic Dermatitis

Frequently asked questions

Which is cheaper, Silvadene or Sodium Sulfacetamide?

Sodium Sulfacetamide costs pharmacies less to acquire — about $0.11 vs $0.25 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Silvadene and Sodium Sulfacetamide?

Silvadene contains Silver Sulfadiazine, while Sodium Sulfacetamide contains Sulfacetamide Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.