SERTRALINE HYDROCHLORIDE vs ZOLOFT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Attribute	SERTRALINE HYDROCHLORIDE	ZOLOFT
Rating	70/100	70/100
Pharmacy pays	~$1.09 /30	~$1.09 /30
Type	RX	RX
Active ingredient	SERTRALINE HYDROCHLORIDE	SERTRALINE HYDROCHLORIDE
Manufacturer	Ascent Pharms Inc	Viatris
Dosage forms	Solution, Tablet	Solution, Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 26 hours	about 26 hours
Treats	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

sertraline hydrochloride zoloft

Rating

70/100

Pharmacy pays

~$1.09 /30

Type

Active ingredient

SERTRALINE HYDROCHLORIDE

Manufacturer

Ascent Pharms Inc

Viatris

Dosage forms

Solution, Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

Half-life

about 26 hours

Treats

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

Which is better-rated, Sertraline Hydrochloride or Zoloft?

Sertraline Hydrochloride and Zoloft are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Sertraline Hydrochloride or Zoloft?

Pharmacies pay about the same to acquire either one — roughly $1.09 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Sertraline Hydrochloride and Zoloft?

Both Sertraline Hydrochloride and Zoloft share the active ingredient Sertraline Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.