SELFEMRA vs ZOLOFT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. SELFEMRA and ZOLOFT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SELFEMRA	ZOLOFT
Rating	56/100	70/100
Pharmacy pays	$0.05 /mL	~$1.09 /30
Type	RX	RX
Active ingredient	FLUOXETINE HYDROCHLORIDE	SERTRALINE HYDROCHLORIDE
Manufacturer	Teva	Viatris
Dosage forms	Tablet	Solution, Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use	about 26 hours
Treats	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

selfemra zoloft

Rating

56/100

70/100

Pharmacy pays

$0.05 /mL

~$1.09 /30

Type

Active ingredient

FLUOXETINE HYDROCHLORIDE

SERTRALINE HYDROCHLORIDE

Manufacturer

Teva

Viatris

Dosage forms

Tablet

Solution, Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

about 26 hours

Treats

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

Which is better-rated, Selfemra or Zoloft?

By our independent rating, Zoloft scores higher — 3.5 vs 2.8 out of 5 for Selfemra. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Selfemra and Zoloft?

Selfemra contains Fluoxetine Hydrochloride, while Zoloft contains Sertraline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.