SAVELLA vs TRINTELLIX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. SAVELLA and TRINTELLIX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SAVELLA	TRINTELLIX
Rating	72/100	New
Pharmacy pays	~$97.10 /30	—
Type	RX	RX
Active ingredient	MILNACIPRAN HYDROCHLORIDE	VORTIOXETINE HYDROBROMIDE
Manufacturer	Abbvie	Takeda Pharms USA
Dosage forms	Kit, Tablet	Tablet
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	—
Boxed warning	Boxed warning	Boxed warning
Treats	Major Depressive Disorder	Major Depressive Disorder

savella trintellix

Rating

72/100

New

Pharmacy pays

~$97.10 /30

—

Type

Active ingredient

MILNACIPRAN HYDROCHLORIDE

VORTIOXETINE HYDROBROMIDE

Manufacturer

Abbvie

Takeda Pharms USA

Dosage forms

Kit, Tablet

Tablet

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

—

Boxed warning

Treats

Major Depressive Disorder

Frequently asked questions

What is the difference between Savella and Trintellix?

Savella contains Milnacipran Hydrochloride, while Trintellix contains Vortioxetine Hydrobromide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.