RYZOLT vs ULTIVA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. RYZOLT and ULTIVA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RYZOLT	ULTIVA
Rating	New	70/100
Pharmacy pays	~$0.72 /30	—
Type	RX	RX
Active ingredient	TRAMADOL HYDROCHLORIDE	REMIFENTANIL HYDROCHLORIDE
Manufacturer	Purdue Pharma	Mylan Institutional
Dosage forms	Tablet, extended release	Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)	—
Treats	Pain	Pain

ryzolt ultiva

Rating

New

70/100

Pharmacy pays

~$0.72 /30

—

Type

Active ingredient

TRAMADOL HYDROCHLORIDE

REMIFENTANIL HYDROCHLORIDE

Manufacturer

Purdue Pharma

Mylan Institutional

Dosage forms

Tablet, extended release

Injectable

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

—

Treats

Pain

Frequently asked questions

What is the difference between Ryzolt and Ultiva?

Ryzolt contains Tramadol Hydrochloride, while Ultiva contains Remifentanil Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.