RYZOLT vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. RYZOLT and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RYZOLT	SUBLIMAZE PRESERVATIVE FREE
Rating	New	72/100
Pharmacy pays	~$0.72 /30	$9.51 /mL
Type	RX	RX
Active ingredient	TRAMADOL HYDROCHLORIDE	FENTANYL CITRATE
Manufacturer	Purdue Pharma	Rising
Dosage forms	Tablet, extended release	Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)	—
Treats	Pain	Pain

ryzolt sublimaze preservative free

Rating

New

72/100

Pharmacy pays

~$0.72 /30

$9.51 /mL

Type

Active ingredient

TRAMADOL HYDROCHLORIDE

FENTANYL CITRATE

Manufacturer

Purdue Pharma

Rising

Dosage forms

Tablet, extended release

Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

—

Treats

Pain

Frequently asked questions

What is the difference between Ryzolt and Sublimaze Preservative Free?

Ryzolt contains Tramadol Hydrochloride, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.