RYTHMOL SR vs TIKOSYN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. RYTHMOL SR and TIKOSYN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RYTHMOL SR	TIKOSYN
Rating	70/100	60/100
Pharmacy pays	~$10.51 /30	~$5.80 /30
Type	RX	RX
Active ingredient	PROPAFENONE HYDROCHLORIDE	DOFETILIDE
Manufacturer	Glaxosmithkline	Pfizer
Dosage forms	Capsule, extended release	Capsule
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	None	Boxed warning
Half-life	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers	—
Treats	Atrial Fibrillation, Supraventricular Tachycardia	Atrial Fibrillation, Atrial Flutter

rythmol sr tikosyn

Rating

70/100

60/100

Pharmacy pays

~$10.51 /30

~$5.80 /30

Type

Active ingredient

PROPAFENONE HYDROCHLORIDE

DOFETILIDE

Manufacturer

Glaxosmithkline

Pfizer

Dosage forms

Capsule, extended release

Capsule

Drug class

Antiarrhythmic

Boxed warning

None

Boxed warning

Half-life

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

—

Treats

Atrial Fibrillation, Supraventricular Tachycardia

Atrial Fibrillation, Atrial Flutter

Frequently asked questions

Which is better-rated, Rythmol SR or Tikosyn?

By our independent rating, Rythmol SR scores higher — 3.5 vs 3.0 out of 5 for Tikosyn. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Rythmol SR or Tikosyn?

Tikosyn costs pharmacies less to acquire — about $5.80 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Rythmol SR and Tikosyn?

Rythmol SR contains Propafenone Hydrochloride, while Tikosyn contains Dofetilide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.