RISPERDAL vs ZYPREXA ZYDIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. RISPERDAL and ZYPREXA ZYDIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RISPERDAL	ZYPREXA ZYDIS
Rating	70/100	New
Pharmacy pays	~$2.07 /30	~$4.13 /30
Type	RX	RX
Active ingredient	RISPERIDONE	OLANZAPINE
Manufacturer	Janssen Pharms	Cheplapharm
Dosage forms	Solution, Tablet	Tablet, orally disintegrating
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)	about 21 to 54 hours (mean around 30 hours)
Treats	Autistic Disorder, Bipolar Disorder, Dementia	Bipolar Disorder, Psychotic Disorders, Schizophrenia

risperdal zyprexa zydis

Rating

70/100

New

Pharmacy pays

~$2.07 /30

~$4.13 /30

Type

Active ingredient

RISPERIDONE

OLANZAPINE

Manufacturer

Janssen Pharms

Cheplapharm

Dosage forms

Solution, Tablet

Tablet, orally disintegrating

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)

about 21 to 54 hours (mean around 30 hours)

Treats

Autistic Disorder, Bipolar Disorder, Dementia

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Frequently asked questions

Which is cheaper, Risperdal or Zyprexa Zydis?

Risperdal costs pharmacies less to acquire — about $2.07 vs $4.13 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Risperdal and Zyprexa Zydis?

Risperdal contains Risperidone, while Zyprexa Zydis contains Olanzapine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.