RISPERDAL vs SEROQUEL XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. RISPERDAL and SEROQUEL XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RISPERDAL	SEROQUEL XR
Rating	70/100	New
Pharmacy pays	~$2.07 /30	~$2.62 /30
Type	RX	RX
Active ingredient	RISPERIDONE	QUETIAPINE FUMARATE
Manufacturer	Janssen Pharms	Cheplapharm Arzneimittel Gmbh
Dosage forms	Solution, Tablet	Tablet, extended release
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	None
Half-life	about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)	about 6 hours
Treats	Autistic Disorder, Bipolar Disorder, Dementia	Autistic Disorder, Bipolar Disorder, Major Depressive Disorder

risperdal seroquel xr

Rating

70/100

New

Pharmacy pays

~$2.07 /30

~$2.62 /30

Type

Active ingredient

RISPERIDONE

QUETIAPINE FUMARATE

Manufacturer

Janssen Pharms

Cheplapharm Arzneimittel Gmbh

Dosage forms

Solution, Tablet

Tablet, extended release

Drug class

Atypical Antipsychotic

Boxed warning

None

Half-life

about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)

about 6 hours

Treats

Autistic Disorder, Bipolar Disorder, Dementia

Autistic Disorder, Bipolar Disorder, Major Depressive Disorder

Frequently asked questions

Which is cheaper, Risperdal or Seroquel XR?

Risperdal costs pharmacies less to acquire — about $2.07 vs $2.62 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Risperdal and Seroquel XR?

Risperdal contains Risperidone, while Seroquel XR contains Quetiapine Fumarate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.