RIFADIN vs XIFAXAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. RIFADIN and XIFAXAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RIFADIN	XIFAXAN
Rating	70/100	New
Pharmacy pays	~$20.59 /30	—
Type	RX	RX
Active ingredient	RIFAMPIN	RIFAXIMIN
Manufacturer	Sanofi Aventis US	Salix
Dosage forms	Injectable	Tablet
Drug class	Rifamycin Antibacterial	Rifamycin Antibacterial
Boxed warning	None	None
Treats	Brucellosis, Haemophilus Infections, Legionnaires' Disease	Diarrhea, Irritable Bowel Syndrome

rifadin xifaxan

Rating

70/100

New

Pharmacy pays

~$20.59 /30

—

Type

Active ingredient

RIFAMPIN

RIFAXIMIN

Manufacturer

Sanofi Aventis US

Salix

Dosage forms

Injectable

Tablet

Drug class

Rifamycin Antibacterial

Boxed warning

None

Treats

Brucellosis, Haemophilus Infections, Legionnaires' Disease

Diarrhea, Irritable Bowel Syndrome

Frequently asked questions

What is the difference between Rifadin and Xifaxan?

Rifadin contains Rifampin, while Xifaxan contains Rifaximin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.