REXULTI vs RISPERDAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. REXULTI and RISPERDAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	REXULTI	RISPERDAL
Rating	New	70/100
Pharmacy pays	—	~$2.07 /30
Type	RX	RX
Active ingredient	BREXPIPRAZOLE	RISPERIDONE
Manufacturer	Otsuka	Janssen Pharms
Dosage forms	Tablet, Kit	Solution, Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)
Treats	Major Depressive Disorder, Schizophrenia	Autistic Disorder, Bipolar Disorder, Dementia

rexulti risperdal

Rating

New

70/100

Pharmacy pays

—

~$2.07 /30

Type

Active ingredient

BREXPIPRAZOLE

RISPERIDONE

Manufacturer

Otsuka

Janssen Pharms

Dosage forms

Tablet, Kit

Solution, Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

—

about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)

Treats

Major Depressive Disorder, Schizophrenia

Autistic Disorder, Bipolar Disorder, Dementia

Frequently asked questions

What is the difference between Rexulti and Risperdal?

Rexulti contains Brexpiprazole, while Risperdal contains Risperidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.