RETIN-A vs SYNALGOS-DC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. RETIN-A and SYNALGOS-DC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RETIN-A	SYNALGOS-DC
Rating	74/100	62/100
Pharmacy pays	$1.05 /g	~$0.78 /30
Type	RX	RX
Active ingredient	TRETINOIN	ASPIRIN AND CAFFEINE AND DIHYDROCODEINE BITARTRATE
Manufacturer	Valeant Pharm Intl	Sun Pharm Industries
Dosage forms	Topical	Capsule
Drug class	Retinoid	—
Boxed warning	None	None
Half-life	—	about 20 minutes (the label also states 0.33 hours) for aspirin itself
Treats	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia	—

retin-a synalgos-dc

Rating

74/100

62/100

Pharmacy pays

$1.05 /g

~$0.78 /30

Type

Active ingredient

TRETINOIN

ASPIRIN AND CAFFEINE AND DIHYDROCODEINE BITARTRATE

Manufacturer

Valeant Pharm Intl

Sun Pharm Industries

Dosage forms

Topical

Capsule

Drug class

Retinoid

—

Boxed warning

None

Half-life

—

about 20 minutes (the label also states 0.33 hours) for aspirin itself

Treats

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

—

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Frequently asked questions

Which is better-rated, Retin-A or Synalgos-Dc?

By our independent rating, Retin-A scores higher — 3.7 vs 3.1 out of 5 for Synalgos-Dc. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Retin-A and Synalgos-Dc?

Retin-A contains Tretinoin, while Synalgos-Dc contains Aspirin and Caffeine and Dihydrocodeine Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.