RETIN-A vs SEMPREX-D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. RETIN-A and SEMPREX-D are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RETIN-A	SEMPREX-D
Rating	74/100	New
Pharmacy pays	$1.05 /g	—
Type	RX	RX
Active ingredient	TRETINOIN	ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Endo Operations
Dosage forms	Topical	Capsule
Drug class	Retinoid	—
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia	—

retin-a semprex-d

Rating

74/100

New

Pharmacy pays

$1.05 /g

—

Type

Active ingredient

TRETINOIN

ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Endo Operations

Dosage forms

Topical

Capsule

Drug class

Retinoid

—

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

—

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Frequently asked questions

What is the difference between Retin-A and Semprex-D?

Retin-A contains Tretinoin, while Semprex-D contains Acrivastine and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.