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RETIN-A vs RYALTRIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. RETIN-A and RYALTRIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
New

Pharmacy pays

$1.05 /g
$0.41 /g

Type

RX
RX

Active ingredient

TRETINOIN
MOMETASONE FUROATE AND OLOPATADINE HYDROCHLORIDE

Dosage forms

Topical
Spray/Inhaler, metered

Drug class

Retinoid
—

Boxed warning

None
None

Treats

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia
—

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Frequently asked questions

Which is cheaper, Retin-A or Ryaltris?

Ryaltris costs pharmacies less to acquire — about $0.41 vs $1.05 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Retin-A and Ryaltris?

Retin-A contains Tretinoin, while Ryaltris contains Mometasone Furoate and Olopatadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.