RESTASIS vs SPEVIGO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. RESTASIS and SPEVIGO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RESTASIS	SPEVIGO
Rating	72/100	72/100
Pharmacy pays	~$52.85 /30	—
Type	RX	RX
Active ingredient	CYCLOSPORINE	SPESOLIMAB-SBZO
Manufacturer	Allergan	Boehringer Ingelheim
Dosage forms	Emulsion	Injectable
Drug class	Calcineurin Inhibitor Immunosuppressant	—
Boxed warning	None	None
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Psoriasis

restasis spevigo

Rating

72/100

Pharmacy pays

~$52.85 /30

—

Type

Active ingredient

CYCLOSPORINE

SPESOLIMAB-SBZO

Manufacturer

Allergan

Boehringer Ingelheim

Dosage forms

Emulsion

Injectable

Drug class

Calcineurin Inhibitor Immunosuppressant

—

Boxed warning

None

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Psoriasis

Frequently asked questions

Which is better-rated, Restasis or Spevigo?

Restasis and Spevigo are tied at 3.6 out of 5 by our independent rating.

What is the difference between Restasis and Spevigo?

Restasis contains Cyclosporine, while Spevigo contains Spesolimab-Sbzo — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.