REPATHA vs ZETIA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. REPATHA and ZETIA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	REPATHA	ZETIA
Rating	72/100	70/100
Pharmacy pays	—	~$2.17 /30
Type	RX	RX
Active ingredient	EVOLOCUMAB	EZETIMIBE
Manufacturer	Amgen Inc	Organon
Dosage forms	Injectable	Tablet
Drug class	—	Dietary Cholesterol Absorption Inhibitor
Boxed warning	None	None
Half-life	—	about 22 hours
Treats	Hypercholesterolemia, Atherosclerosis	Hypercholesterolemia, Hyperlipoproteinemia Type II, Familial Combined Hyperlipidemia

repatha zetia

Rating

72/100

70/100

Pharmacy pays

—

~$2.17 /30

Type

Active ingredient

EVOLOCUMAB

EZETIMIBE

Manufacturer

Amgen Inc

Organon

Dosage forms

Injectable

Tablet

Drug class

—

Dietary Cholesterol Absorption Inhibitor

Boxed warning

None

Half-life

—

about 22 hours

Treats

Hypercholesterolemia, Atherosclerosis

Hypercholesterolemia, Hyperlipoproteinemia Type II, Familial Combined Hyperlipidemia

Frequently asked questions

Which is better-rated, Repatha or Zetia?

By our independent rating, Repatha scores higher — 3.6 vs 3.5 out of 5 for Zetia. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Repatha and Zetia?

Repatha contains Evolocumab, while Zetia contains Ezetimibe — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.