RAPAMUNE vs SPRYCEL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. RAPAMUNE and SPRYCEL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RAPAMUNE	SPRYCEL
Rating	New	72/100
Pharmacy pays	~$48.61 /30	~$839.19 /30
Type	RX	RX
Active ingredient	SIROLIMUS	DASATINIB
Manufacturer	Pf Prism Cv	Bristol Myers Squibb
Dosage forms	Solution	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	Boxed warning	None
Treats	Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms	Lymphoid Leukemia, Myeloid Leukemia

rapamune sprycel

Rating

New

72/100

Pharmacy pays

~$48.61 /30

~$839.19 /30

Type

Active ingredient

SIROLIMUS

DASATINIB

Manufacturer

Pf Prism Cv

Bristol Myers Squibb

Dosage forms

Solution

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

Lymphoid Leukemia, Myeloid Leukemia

Frequently asked questions

Which is cheaper, Rapamune or Sprycel?

Rapamune costs pharmacies less to acquire — about $48.61 vs $839.19 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Rapamune and Sprycel?

Rapamune contains Sirolimus, while Sprycel contains Dasatinib — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.