RALOXIFENE HYDROCHLORIDE vs SEROPHENE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. RALOXIFENE HYDROCHLORIDE and SEROPHENE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RALOXIFENE HYDROCHLORIDE	SEROPHENE
Rating	70/100	70/100
Pharmacy pays	~$7.21 /30	~$183.46 /30
Type	RX	RX
Active ingredient	RALOXIFENE HYDROCHLORIDE	CLOMIPHENE CITRATE
Manufacturer	Invagen Pharms	Emd Serono
Dosage forms	Tablet	Tablet
Drug class	Estrogen Agonist/Antagonist	Estrogen Agonist/Antagonist
Boxed warning	Boxed warning	None
Treats	Postmenopausal Osteoporosis	Female Infertility, Male Infertility

raloxifene hydrochloride serophene

Rating

70/100

Pharmacy pays

~$7.21 /30

~$183.46 /30

Type

Active ingredient

RALOXIFENE HYDROCHLORIDE

CLOMIPHENE CITRATE

Manufacturer

Invagen Pharms

Emd Serono

Dosage forms

Tablet

Drug class

Estrogen Agonist/Antagonist

Boxed warning

None

Treats

Postmenopausal Osteoporosis

Female Infertility, Male Infertility

Frequently asked questions

Which is better-rated, Raloxifene Hydrochloride or Serophene?

Raloxifene Hydrochloride and Serophene are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Raloxifene Hydrochloride or Serophene?

Raloxifene Hydrochloride costs pharmacies less to acquire — about $7.21 vs $183.46 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Raloxifene Hydrochloride and Serophene?

Raloxifene Hydrochloride contains Raloxifene Hydrochloride, while Serophene contains Clomiphene Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.