QUILLIVANT XR vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 30, 2026·How we rate

Possible drug interaction. QUILLIVANT XR and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	QUILLIVANT XR	VYVANSE
Rating	New	New
Pharmacy pays	~$18.94 /30	—
Type	RX	RX
Active ingredient	METHYLPHENIDATE HYDROCHLORIDE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Nextwave	Takeda Pharms USA
Dosage forms	Suspension, extended release	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2.7 hours	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

quillivant xr vyvanse

Rating

New

Pharmacy pays

~$18.94 /30

—

Type

Active ingredient

METHYLPHENIDATE HYDROCHLORIDE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Nextwave

Takeda Pharms USA

Dosage forms

Suspension, extended release

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 2.7 hours

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Quillivant XR and Vyvanse?

Quillivant XR contains Methylphenidate Hydrochloride, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.