PROZAC vs SERTRALINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PROZAC and SERTRALINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROZAC	SERTRALINE HYDROCHLORIDE
Rating	New	70/100
Pharmacy pays	$0.05 /mL	~$1.09 /30
Type	RX	RX
Active ingredient	FLUOXETINE HYDROCHLORIDE	SERTRALINE HYDROCHLORIDE
Manufacturer	Eli Lilly and Co	Ascent Pharms Inc
Dosage forms	Capsule	Solution, Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use	about 26 hours
Treats	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

prozac sertraline hydrochloride

Rating

New

70/100

Pharmacy pays

$0.05 /mL

~$1.09 /30

Type

Active ingredient

FLUOXETINE HYDROCHLORIDE

SERTRALINE HYDROCHLORIDE

Manufacturer

Eli Lilly and Co

Ascent Pharms Inc

Dosage forms

Capsule

Solution, Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

Half-life

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

about 26 hours

Treats

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

What is the difference between Prozac and Sertraline Hydrochloride?

Prozac contains Fluoxetine Hydrochloride, while Sertraline Hydrochloride contains Sertraline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.