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PROZAC vs SARAFEM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

$0.05 /mL
$0.05 /mL

Type

RX
RX

Active ingredient

FLUOXETINE HYDROCHLORIDE
FLUOXETINE HYDROCHLORIDE

Dosage forms

Capsule
Capsule

Drug class

Serotonin Reuptake Inhibitor
Serotonin Reuptake Inhibitor

Half-life

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use
about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

Treats

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder
Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

Frequently asked questions

Which is cheaper, Prozac or Sarafem?

Pharmacies pay about the same to acquire either one — roughly $0.05 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Prozac and Sarafem?

Both Prozac and Sarafem share the active ingredient Fluoxetine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.