PROTOPIC vs RESTASIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. PROTOPIC and RESTASIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROTOPIC	RESTASIS
Rating	New	72/100
Pharmacy pays	$0.65 /g	~$52.85 /30
Type	RX	RX
Active ingredient	TACROLIMUS	CYCLOSPORINE
Manufacturer	Leo Pharma As	Allergan
Dosage forms	Topical	Emulsion
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	None	None
Half-life	—	about 8.4 hours (range 5 to 18 hours)
Treats	Atopic Dermatitis, Graft Vs Host Disease	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

protopic restasis

Rating

New

72/100

Pharmacy pays

$0.65 /g

~$52.85 /30

Type

Active ingredient

TACROLIMUS

CYCLOSPORINE

Manufacturer

Leo Pharma As

Allergan

Dosage forms

Topical

Emulsion

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Half-life

—

about 8.4 hours (range 5 to 18 hours)

Treats

Atopic Dermatitis, Graft Vs Host Disease

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Frequently asked questions

What is the difference between Protopic and Restasis?

Protopic contains Tacrolimus, while Restasis contains Cyclosporine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.