PROPAFENONE HYDROCHLORIDE vs RYTHMOL SR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	PROPAFENONE HYDROCHLORIDE	RYTHMOL SR
Rating	72/100	70/100
Pharmacy pays	~$10.51 /30	~$10.51 /30
Type	RX	RX
Active ingredient	PROPAFENONE HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Rising	Glaxosmithkline
Dosage forms	Capsule, extended release, Tablet	Capsule, extended release
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	Boxed warning	None
Half-life	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Atrial Fibrillation, Supraventricular Tachycardia	Atrial Fibrillation, Supraventricular Tachycardia

propafenone hydrochloride rythmol sr

Rating

72/100

70/100

Pharmacy pays

~$10.51 /30

Type

Active ingredient

PROPAFENONE HYDROCHLORIDE

Manufacturer

Rising

Glaxosmithkline

Dosage forms

Capsule, extended release, Tablet

Capsule, extended release

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Propafenone Hydrochloride or Rythmol SR?

By our independent rating, Propafenone Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Rythmol SR. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Propafenone Hydrochloride or Rythmol SR?

Pharmacies pay about the same to acquire either one — roughly $10.51 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Propafenone Hydrochloride and Rythmol SR?

Both Propafenone Hydrochloride and Rythmol SR share the active ingredient Propafenone Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.