PROPAFENONE HYDROCHLORIDE vs QUINIDINE SULFATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. PROPAFENONE HYDROCHLORIDE and QUINIDINE SULFATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROPAFENONE HYDROCHLORIDE	QUINIDINE SULFATE
Rating	72/100	New
Pharmacy pays	~$10.51 /30	~$326.26 /30
Type	RX	RX
Active ingredient	PROPAFENONE HYDROCHLORIDE	QUINIDINE SULFATE
Manufacturer	Rising	Halsey
Dosage forms	Capsule, extended release, Tablet	Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	Boxed warning	None
Half-life	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers	—
Treats	Atrial Fibrillation, Supraventricular Tachycardia	Atrial Fibrillation, Atrial Flutter

propafenone hydrochloride quinidine sulfate

Rating

72/100

New

Pharmacy pays

~$10.51 /30

~$326.26 /30

Type

Active ingredient

PROPAFENONE HYDROCHLORIDE

QUINIDINE SULFATE

Manufacturer

Rising

Halsey

Dosage forms

Capsule, extended release, Tablet

Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

—

Treats

Atrial Fibrillation, Supraventricular Tachycardia

Atrial Fibrillation, Atrial Flutter

Frequently asked questions

Which is cheaper, Propafenone Hydrochloride or Quinidine Sulfate?

Propafenone Hydrochloride costs pharmacies less to acquire — about $10.51 vs $326.26 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Propafenone Hydrochloride and Quinidine Sulfate?

Propafenone Hydrochloride contains Propafenone Hydrochloride, while Quinidine Sulfate contains Quinidine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.