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PROLIXIN vs PROMETHAZINE PLAIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PROLIXIN and PROMETHAZINE PLAIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

~$11.42 /30
~$1.53 /30

Type

RX
RX

Active ingredient

FLUPHENAZINE HYDROCHLORIDE
PROMETHAZINE HYDROCHLORIDE

Dosage forms

Tablet
Syrup

Drug class

Phenothiazine
Phenothiazine

Boxed warning

Half-life

about 9 to 16 hours

Treats

Psychotic Disorders, Schizophrenia
Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is cheaper, Prolixin or Promethazine Plain?

Promethazine Plain costs pharmacies less to acquire — about $1.53 vs $11.42 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prolixin and Promethazine Plain?

Prolixin contains Fluphenazine Hydrochloride, while Promethazine Plain contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.