PROLENSA vs VOLTAREN-XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. PROLENSA and VOLTAREN-XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROLENSA	VOLTAREN-XR
Rating	New	70/100
Pharmacy pays	$14.72 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	BROMFENAC SODIUM	DICLOFENAC SODIUM
Manufacturer	Bausch and Lomb	Novartis
Dosage forms	Drops	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	—	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Inflammation, Postoperative Pain, Eye Pain	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

prolensa voltaren-xr

Rating

New

70/100

Pharmacy pays

$14.72 /mL

$0.36 /mL

Type

Active ingredient

BROMFENAC SODIUM

DICLOFENAC SODIUM

Manufacturer

Bausch and Lomb

Novartis

Dosage forms

Drops

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

—

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Inflammation, Postoperative Pain, Eye Pain

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Prolensa or Voltaren-XR?

Voltaren-XR costs pharmacies less to acquire — about $0.36 vs $14.72 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prolensa and Voltaren-XR?

Prolensa contains Bromfenac Sodium, while Voltaren-XR contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.