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PROGRAF vs PROTOPIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Rating

72/100
New

Pharmacy pays

$0.65 /g
$0.65 /g

Type

RX
RX

Active ingredient

TACROLIMUS
TACROLIMUS

Dosage forms

Capsule, Powder, Injectable
Topical

Drug class

Calcineurin Inhibitor Immunosuppressant
Calcineurin Inhibitor Immunosuppressant

Boxed warning

Treats

Atopic Dermatitis, Graft Vs Host Disease
Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

Which is cheaper, Prograf or Protopic?

Pharmacies pay about the same to acquire either one — roughly $0.65 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Prograf and Protopic?

Both Prograf and Protopic share the active ingredient Tacrolimus.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.