PROCHLORPERAZINE vs STELAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. PROCHLORPERAZINE and STELAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROCHLORPERAZINE	STELAZINE
Rating	70/100	70/100
Pharmacy pays	~$5.22 /30	~$22.02 /30
Type	RX	RX
Active ingredient	PROCHLORPERAZINE MALEATE	TRIFLUOPERAZINE HYDROCHLORIDE
Manufacturer	Watson Labs	Glaxosmithkline
Dosage forms	Suppository, Tablet	Tablet
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	None
Treats	Anxiety Disorders, Dementia, Nausea	Anxiety Disorders, Psychotic Disorders, Schizophrenia

prochlorperazine stelazine

Rating

70/100

Pharmacy pays

~$5.22 /30

~$22.02 /30

Type

Active ingredient

PROCHLORPERAZINE MALEATE

TRIFLUOPERAZINE HYDROCHLORIDE

Manufacturer

Watson Labs

Glaxosmithkline

Dosage forms

Suppository, Tablet

Tablet

Drug class

Phenothiazine

Boxed warning

None

Treats

Anxiety Disorders, Dementia, Nausea

Anxiety Disorders, Psychotic Disorders, Schizophrenia

Frequently asked questions

Which is better-rated, Prochlorperazine or Stelazine?

Prochlorperazine and Stelazine are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Prochlorperazine or Stelazine?

Prochlorperazine costs pharmacies less to acquire — about $5.22 vs $22.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prochlorperazine and Stelazine?

Prochlorperazine contains Prochlorperazine Maleate, while Stelazine contains Trifluoperazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.