PROCHLORPERAZINE vs PROMETHEGAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. PROCHLORPERAZINE and PROMETHEGAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROCHLORPERAZINE	PROMETHEGAN
Rating	70/100	70/100
Pharmacy pays	~$5.22 /30	~$1.53 /30
Type	RX	RX
Active ingredient	PROCHLORPERAZINE MALEATE	PROMETHAZINE HYDROCHLORIDE
Manufacturer	Watson Labs	Cosette
Dosage forms	Suppository, Tablet	Suppository
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	Boxed warning
Half-life	—	about 9 to 16 hours
Treats	Anxiety Disorders, Dementia, Nausea	Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

prochlorperazine promethegan

Rating

70/100

Pharmacy pays

~$5.22 /30

~$1.53 /30

Type

Active ingredient

PROCHLORPERAZINE MALEATE

PROMETHAZINE HYDROCHLORIDE

Manufacturer

Watson Labs

Cosette

Dosage forms

Suppository, Tablet

Suppository

Drug class

Phenothiazine

Boxed warning

None

Boxed warning

Half-life

—

about 9 to 16 hours

Treats

Anxiety Disorders, Dementia, Nausea

Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is better-rated, Prochlorperazine or Promethegan?

Prochlorperazine and Promethegan are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Prochlorperazine or Promethegan?

Promethegan costs pharmacies less to acquire — about $1.53 vs $5.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prochlorperazine and Promethegan?

Prochlorperazine contains Prochlorperazine Maleate, while Promethegan contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.