PRIMSOL vs PROLOPRIM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PRIMSOL and PROLOPRIM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PRIMSOL	PROLOPRIM
Rating	New	New
Pharmacy pays	~$35.33 /30	~$35.33 /30
Type	RX	RX
Active ingredient	TRIMETHOPRIM HYDROCHLORIDE	TRIMETHOPRIM
Manufacturer	Pangea	Monarch Pharms
Dosage forms	Solution	Tablet
Drug class	Dihydrofolate Reductase Inhibitor Antibacterial	Dihydrofolate Reductase Inhibitor Antibacterial
Boxed warning	None	None
Half-life	about 8 to 10 hours	about 8 to 10 hours
Treats	Bronchitis, Escherichia Coli Infections, Klebsiella Infections	Bronchitis, Escherichia Coli Infections, Klebsiella Infections

primsol proloprim

Rating

New

Pharmacy pays

~$35.33 /30

Type

Active ingredient

TRIMETHOPRIM HYDROCHLORIDE

TRIMETHOPRIM

Manufacturer

Pangea

Monarch Pharms

Dosage forms

Solution

Tablet

Drug class

Dihydrofolate Reductase Inhibitor Antibacterial

Boxed warning

None

Half-life

about 8 to 10 hours

Treats

Bronchitis, Escherichia Coli Infections, Klebsiella Infections

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Frequently asked questions

Which is cheaper, Primsol or Proloprim?

Pharmacies pay about the same to acquire either one — roughly $35.33 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Primsol and Proloprim?

Primsol contains Trimethoprim Hydrochloride, while Proloprim contains Trimethoprim — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.