PRIMIDONE vs ZONISADE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. PRIMIDONE and ZONISADE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PRIMIDONE	ZONISADE
Rating	70/100	70/100
Pharmacy pays	~$2.89 /30	~$3.16 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ZONISAMIDE
Manufacturer	Amneal	Azurity
Dosage forms	Tablet	Suspension
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	Partial Epilepsies

primidone zonisade

Rating

70/100

Pharmacy pays

~$2.89 /30

~$3.16 /30

Type

Active ingredient

PRIMIDONE

ZONISAMIDE

Manufacturer

Amneal

Azurity

Dosage forms

Tablet

Suspension

Drug class

Anti-Epileptic Agent

Boxed warning

None

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Partial Epilepsies

Frequently asked questions

Which is better-rated, Primidone or Zonisade?

Primidone and Zonisade are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Primidone or Zonisade?

Primidone costs pharmacies less to acquire — about $2.89 vs $3.16 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Primidone and Zonisade?

Primidone contains Primidone, while Zonisade contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.