PREVACID IV vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PREVACID IV and PRILOSEC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PREVACID IV	PRILOSEC
Rating	New	70/100
Pharmacy pays	~$5.10 /30	~$1.52 /30
Type	RX	RX
Active ingredient	LANSOPRAZOLE	OMEPRAZOLE
Manufacturer	Takeda Pharms Na	Astrazeneca
Dosage forms	Injectable	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

prevacid iv prilosec

Rating

New

70/100

Pharmacy pays

~$5.10 /30

~$1.52 /30

Type

Active ingredient

LANSOPRAZOLE

OMEPRAZOLE

Manufacturer

Takeda Pharms Na

Astrazeneca

Dosage forms

Injectable

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is cheaper, Prevacid IV or Prilosec?

Prilosec costs pharmacies less to acquire — about $1.52 vs $5.10 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prevacid IV and Prilosec?

Prevacid IV contains Lansoprazole, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.