PRESAMINE vs TOFRANIL-PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. PRESAMINE and TOFRANIL-PM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PRESAMINE	TOFRANIL-PM
Rating	70/100	70/100
Pharmacy pays	~$2.54 /30	~$100.18 /30
Type	RX	RX
Active ingredient	IMIPRAMINE HYDROCHLORIDE	IMIPRAMINE PAMOATE
Manufacturer	Sanofi Aventis US	Specgx LLC
Dosage forms	Tablet	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

presamine tofranil-pm

Rating

70/100

Pharmacy pays

~$2.54 /30

~$100.18 /30

Type

Active ingredient

IMIPRAMINE HYDROCHLORIDE

IMIPRAMINE PAMOATE

Manufacturer

Sanofi Aventis US

Specgx LLC

Dosage forms

Tablet

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Presamine or Tofranil-Pm?

Presamine and Tofranil-Pm are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Presamine or Tofranil-Pm?

Presamine costs pharmacies less to acquire — about $2.54 vs $100.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Presamine and Tofranil-Pm?

Presamine contains Imipramine Hydrochloride, while Tofranil-Pm contains Imipramine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.